You're right, aside from Indiana Jones in 2008, the last hit he had was "What Lies Beneath", that ghost movie with Michelle Pfeiffer in 2000

Even "Cowboys and Aliens" with Daniel Craig wasn't a big hit

Jeff Bridges and Robert Downey Jr. signed for Iron Man, and Clooney for "Batman and Awful", so that takes care of those big stars.
Al Pacino signed for a Panini set a couple of years back, but cards from Nicholson, Eastwood, Tom Hanks, Sean Connery, DeNiro, Robert Redford, or Tom Cruise would all be huge. Nicholas Cage, Christian Bale, and Robert Duvall would be most welcome, too.

In my previous post I forgot to say, Yes, I think Ford is Cryptozoic's biggest autograph score but he would be one of an elite group that would be a superstar score.

Chesspieceface's list is pretty accurate!